Preferred Sample Type
Suitable Specimen Types
- Serum
- EDTA Plasma
- Li Hep Plasma
Sample Processing in Laboratory
Centrifuge and place in toxicology box in cold room.Sample Preparation
UsualTurnaround Time
5 working daysSample Stability
4 ºC
Lamotrigine (Lamictal)
General Information
Lamotrigine is indicated for the treatment of partial and generalised seizures in adults and increasingly, in children. It may also have a role in the treatment of conditions such as Parkinson's disease. Adverse reactions are relativel minor, for example: (nausea, headache and dizziness). A typical dosage for Lamotrigine is 200-400 mg. bd. The half-life of the drug is around 24hours; although this is affected by concomitant therapy. Lamotrigine is known to delay the metabolism of carbamzepine and may also interact with other drugs.
Patient Preparation
Trough specimen taken pre-dose or minimum 6hrs post-dose
Notes
Measured by LC-MSMS
Please note this assay is not currently UKAS accredited
Reference Range
3-15mg/L NOTE: change to therapeutic range from February 2026, single range for all treated patients
Specifications
- EQA Scheme?: Yes
- EQA Status: NEQAS TDM