No reference ranges applicable. Results must be interpreted with thyroglobulin antibodies (TgAb).
Successfully treated post-thyroidectomy patients should have an undetectable serum thyroglobulin. Elevations in thyroglobulin post-thyroidectomy for DTC can indicate recurrence of disease or metastasis. Thyroglobulin analysis is most sensitive when TSH is not suppressed ie, any small thyroid remnants of disease present should produce measurable thyroglobulin.
Interpretation of results also depends on factors such as whether the patient is on T4/T3 replacement.
Higher levels may be seen in the newborns and in the third trimester of pregnancy.
Benign elevations of thyroglobulin see with:
- Grave's disease
- Hashimoto's disease
- Adenomas
