There is no recommended therapeutic range for valproate
Source : Pathology Harmony Recommendations
The levels in serum do not correlate well with therapeutic/toxic effects and it is generally agreed that monitoring valproate levels is not useful.
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Pre dose (trough) level 10- 15 mg/L.
For more information please see pharmacy guidance (http://pharmacy/?page_id=922)
http://www.heftpathology.com/Microbiology/micro-antibiotic-assay-protocol.html http://www.heftpathology.com/Microbiology/micro-vanc-service.html
37.1 mg/L at week 618.4 mg /L at week 1412.7 mg/L during maintenance treatment.
Therapeutic range = 100 - 400 ug/L (sum of venlafaxine and O-desmethylvenlafaxine (ODV))
Therapeutic use of verapamil is associated with blood concentrations of up to 0.4 mg/L. Toxicity is associated with verapamil levels > 1 mg/L. (Schulz et al. Critical Care 2012, 16:R136).
Age < 1 year
Age >1 year
All ages
C22 (µmol/L)
22.3-85.4
30.3-91.6
C24 (µmol/L)
19.1-65.9
25.0-73.5
C26 (µmol/L)
0.23-1.05
0.28-1.34
C24/C22
0.68-0.97
C26/C22
0.005-0.022
Pristanate (µmol/L)
<0.7
<2.3
Phytanate (µmol/L)
<5
<18
Reference ranges provided by reference laboratory.
Please note, new reference ranges applicable from 1st August 2015.
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Vitamin B1: 66.5 to 200 nmol/L
Vitamin B6: 44 to 168 nmol/L
187-883 ng/L
Source : Abbott Diagnostics
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4-20mg/l Provided by Reference Laboratory
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