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Biochemistry

Referred Work (108)

Blood Sciences - Biochemistry referred work. These tests are available via the standard electronic and paper request cards. Site specific processing will be detailed in the test information. These tests are referred to other laboratories for analysis.

Solihull Biochemistry Laboratory (2)

Solihull Blood Sciences - Biochemistry - Test menu. These tests are available routinely on the Solihull Hospital site and/or may required site specific sample processing. All other biochemistry tests are available, but site specific processing may be required. This section details those tests

Heartlands Biochemistry Laboratory (27)

Heartlands Blood Sciences - Biochemistry - Test menu. These tests are available routinely on the Heartlands site and/or may required site specific sample processing. All other biochemistry tests are available, but site specific processing may be required. This section details those tests

Good Hope Biochemistry Laboratory (2)

Good Hope Blood Sciences - Biochemistry - Test menu. These tests are available routinely on the Good Hope site and/or may required site specific sample processing. All other biochemistry tests are available, but site specific processing may be required. This section details those tests

Gentamicin Antibiotic Assay

Multiple Daily Dosing

Pre dose (trough) blood sample 15 mins before dose <2mg/L

Post dose (peak) blood sample 1 hour after dose 5 - 10mg/L

In endocarditis pre dose <1mg/L and post dose 3 - 5mg/L

N.B. Ranges and comments DO NOT apply to Renal patients

Once Daily Dosing

Post-dose only taken between 6 and 14 hours after dose. Times of dosing and sampling must MUST be given on request form.

Refer to Urban & Craig nomogram to interpet

Please refer to Antibiotic guidelines on the HEFT website for further information (http://pharmacy/?page_id=922)

Microbiology Biochemistry

http://www.heftpathology.com/Microbiology/micro-antibiotic-assay-protocol.html

Glucose (CSF)

Infant/child: 3.33-4.44nmol/L

Adult: 2.22-3.89 mmol/L

(Usually approx 60% of serum glucose value)

Source : Abbott Diagnostics

Biochemistry

http://www.labtestsonline.org.uk/understanding/analytes/csf/csf-exams?start=1

Glucose (Plasma)

3.9-5.8 mmol/L (Fasting)

Source : Abbott Diagnostics

Biochemistry

Glucose Tolerance Test (OGTT)

Levels are influenced by many factors including previous carbohydrate diet, drugs, gastric emptying time and gastrointestinal surgery, as well as circulating insulin levels.

The following criteria for adults and children are based on recommendation made by the World Health Organisation and have been adopted by Diabetes UK.

	Glucose concentration in mmol/L
	Venous plasma	Capillary plasma
Diabetes mellitus
Fasting value	≥ 7.0	≥ 6.1
2h after glucose load	≥11.1	≥ 11.1
Impaired Glucose Tolerance
Fasting Value	< 7.0	< 6.1
2h after glucose load	≥ 7.8 & <11.1	≥ 7.8
Impaired Fasting Glycaemia
FastingValue	≥ 6.1 & <7.0	≥ 5.6 & <6.1
2h after glucose load	< 7.8	< 7.8

NOTE. If the fasting blood glucose concentration is in the diabetic range on more than one occasion, the oral GTT is superfluous.

The same criteria are used for pregnant patients but those fulfilling the criteria of impaired glucose tolerance and diabetes mellitus have gestational diabetes mellitus (GDM).

'Diabetic' levels of glucose are not infrequently found in stressed individuals.

Solihull Biochemistry Laboratory Heartlands Biochemistry Laboratory Good Hope Biochemistry Laboratory Biochemistry

https://pinboard.in/u:duty_biochemist/t:Diabetes/

Glycine in CSF and Blood (to be done simultaneously)

Provided by reference laboratory

Referred Work Biochemistry

Glycosaminoglycans (Mucopolysaccharides) (GAGS)

< 1 year < 58.2 mg/mmol

1 - 2 years < 37.6 mg/mmol

3 - 6 years < 16.6 mg/mmol

7 - 16 years < 13.4 mg/mmol

>16 years < 9.5 mg/mmol

>30 years < 2.7 mg/mmol

Provided by reference laboratory

Referred Work Biochemistry

https://pinboard.in/u:duty_biochemist/t:GAG/

Growth Hormone (GH)

No reference range for Growth Hormone is quoted, as levels can depend upon the time of day, medication and exercise.

Referred Work Biochemistry

https://pinboard.in/u:duty_biochemist/t:GH/

Gut Hormones (glucagon, gastrin, VIP, somatastatin, pancreatic polypeptide)

Provided by Reference Laboratory

Referred Work Biochemistry

https://pinboard.in/u:duty_biochemist/t:GutHormone/

Haptoglobin

	Male (g/L)	Female (g/L)
0 - 1 year old	0.00 - 3.00	0.00 - 2.35
2 - 12 years old	0.03 - 2.70	0.11 - 2.20
13 - 60 years old	0.14 - 2.58	0.35 - 2.50
>60 years old	0.40 - 2.68	0.63 - 2.73

Biochemistry

http://www.labtestsonline.org.uk/understanding/analytes/haptoglobin/tab/glance

HDL Cholesterol

Lower HDL concentrations are asociated with increased risk of cardiovascular disease. The concentration of HDL should be assessed in the context of other risk factors (total cholesterol, smoking, diabetes, hypertension).

Desirable HDL values are:

Males - >1.0 mmol/L

Femailes - >1.2 mmol/L

Biochemistry

http://www.labtestsonline.org.uk/understanding/analytes/hdl/tab/glance

Heterophilic Antibodies

None Given

Biochemistry

Homocysteine/ Homocystine (HCYS)

Deficiencies of the vitamins folic acid (B9), pyridoxine (B6), or B12 (cobalamin) can lead to high homocysteine levels. Supplementation with pyridoxine, folic acid, B12 or trimethylglycine (betaine) reduces the concentration of homocysteine in the bloodstream.

Elevations of homocysteine also occur in the rare hereditary disease homocystinuria and in the methylene-tetrahydrofolate-reductase polymorphism genetic traits. The latter is quite common (about 10% of the world population) and it is linked to an increased incidence of thrombosis and cardiovascular disease.

Sample analysed by tandem mass spectrometry. Please note new reference range as of March 2013.

6.7 - 15.2 µmol/L