TPMT phenotype/activity reference ranges:
<6 nmol/ghb/hr = Deficient
6-34 nmol/gHb/hr = Low
35-79 nmol/gHb/hr = Normal
>79 nmol/gHb/hr = High
TPMT genotype classifications:
WT = wild-type, normal result
H3 = TPMT 1*/3* - heterozygous for TPMT, this would indicate a reduced activity. Advise reduce dose of azothioprine.
H2 = TPMT 1*/2* - heterozygous for TPMT, this would indicate a reduced activity. Advise reduce dose of azothioprine
H03 = TPMT 3*/3* - homozygous for TPMT, this would indicated deficient TPMT activity. Advise stop treatment with azothioprine.
H02 = TPMT 2*/2* - homozygous for TPMT, this would indicated deficient TPMT activity. Advise stop treatment with azothioprine.