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Items starting with M

Methadone

Methadone

Therapeutic use of methadone is typically associated with plasma concentrations of 0.05 to 1.0 mg/L dependent on the dose, with adverse drug reactions being noted in the region of 1 to 2 mg/L for regular users of the drug. (Clarke's Analysis of Drugs & Poisons, Third Edition). 

Methotrexate (MTX)

Methotrexate (MTX)

Times given are from time 0 (time of starting intravenous methotrexate infusion).

The following samples are required for patient's safe rescue with folinic acid:

48 hours, 72 hours, and then every 24 hours until methotrexate level is less than 0.1 µmol/L.

 

Methoxphenidine (MXP)

Methoxphenidine (MXP)

Please contact the laboratory for interpretaion.

Midazolam

Midazolam

Toxicity associated with midazolam levels > 1.0 mg/L. (Schulz et al. Critical Care 2012, 16:R136).

Please contact the laboratory if midazolam measurement is required for therapeutic monitoring purposes.

Mirtazapine

Mirtazapine

Therapeutic range = 30 -80 ug/L

 

Desmethylmirtazapine does not contribute to pharmacological actions.

MMA - Methylmalonic Acid

MMA - Methylmalonic Acid

Age related:   

≤65 yrs   0-280 nmol/L  

>65 yrs    0-360 nmol/L

MMA - Methylmalonic Acid

MMA - Methylmalonic Acid

Age related:   

≤65 yrs   0-280 nmol/L  

>65 yrs    0-360 nmol/L

MODY genetic testing

MODY genetic testing

Interpretation of results will be provided by the referral laboratory.

 

MODY genetic testing

MODY genetic testing

Interpretation of results will be provided by the referral laboratory.

 

Morphine & Metabolites

Morphine & Metabolites

Morphine concentrations > 50 µg/L associated with toxicity. However, interpretation is dependent on the concentrations of metabolites. (Baselt, Disposition of Toxic Drugs and Chemicals in Man, Eighth Edition, 2008).

Please contact the laboratory for further interpretation. 

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