This is a screening test for the presence of sulphonylureas in plasma or urine. As such, we will report results as Positive or Negative for the drugs listed above. All can be detected reliably at concentrations of 0.5 mg/L in urine and plasma.
http://jcp.bmj.com/content/56/9/641.full.pdf
Interpretation is based solely on sweat chloride concentration.
Age
Sweat Chloride concentration (mmol/L)
Interpretation
<6 months
<30
Cystic fibrosis is unlikely but requires genetic and clinical correlation
6 months and over
<40
30-60
Intermediate result which requires further cystic fibrosis assessment
40-60
All ages
>60
Supports a diagnosis of cystic fibrosis
Sweat sodium is used as a check of the chloride result. Interpretation is as follows:
Cystic fibrosis unlikely < 50 mmol/L
Supports the diagnosis of CF > 90 mmol/L
The Sodium and Chloride concentrations should be within 20 mmol/L of each other.
This is a screening test. Drugs detected in specimens will be stated on the report.
THIS ASSAY IS CURRENTLY NOT AVAILABLE
Negative
