American College of Cardiology/European Society of Cardiology suggest setting cardiac biomarker cut off points for the diagnosis of acute coronary syndrom as > 99th centile for the normal population:
Males <6.7 ug/L;
Females < 3.8 ug/L.
NOTES ON INTERPRETATION OF RESULTS:
The CK-MB isoform is not specific to cardiac muscle. It is also found at lower levels in skeletal muscle. CK-MB mass will therefore also be raised, to some extent, in skeletal muscle damage.
A relative index can be calculated using
(CK-MB mass/total CK) x100.
If result >5 - strong possibility of MI,
>3 but <5 - equivocal,
<3 - not likely to be MI.
