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Items starting with C

Codeine

Codeine

Please contact the laboratory if codeine measurement is required for therapeutic monitoring purposes. 

Units ug/L

Copper

Copper

Copper (serum) (CU)

µmol/L

0 – <4 months

1.4 – 7.2

4 – <6 months

3.9 – 17.3

6 months – <9 years

11.1-27.4

9 years – <13 years

11.2-23.7

13 years – 19 years

11.0-22.5

> 19 years

11.0-25.1

Pregnancy: 16 weeks to term

27 - 40

Wilson’s Disease

< 4

(Source: SAS Trace Element Update, 2018)

Cortisol

Cortisol

Before 10 am: 101.2 - 535.7 nmol/L,

After 5 pm: 79 - 477.8 nmol/L,

(Source: Abbott Diagnostics)

Cortisol (Urine)

Reference ranges (corrected for 24 hour collection):

<130nmol/24h

Cotinine

Cotinine

Urine cotinine concentrations below 50 ng/mL have been reported to reflect abstinence from tobacco for 2 or more weeks.

For further information please contact the laboratory

Creatine Kinase (CK)

Creatine Kinase (CK)

Values can vary according to muscle mass of the individual. For this reason we use different reference intervals for males and females and some ethnic differences.

Females: European 29-168 IU/ L (Abbott laboratories)
Females: AfroCarribean < 305 IU/L
Females: South Asian < 200 IU/L

Males: European 30-200 IU/L (Abbott laboratories)
Males: AfroCarribean < 600 IU/L
Males: South Asian < 330 IU/L

Creatinine

Creatinine

Serum creatinine:

64 - 104 µmol/L (Male)

49 - 90 µmol/L (Female)

(Source : Abbott Diagnostics)

Laboratory practice is that eGFR using the 4 variable MDRD equation is applied to males with a creatinine of >111 µmol/L and females with a creatinine >98 µmol/L.

As individuals age they usually lose muscle mass which means that if their renal function remains unaffected creatine concentration in serum should fall as we age. Conventional population based reference intervals have not usually been age stratified. The impact of this is that individuals can have creatinine concentrations within the conventional population reference range while having significant renal impairment.

Note

From Monday 10th September 2018 creatinine will be measured using the enzymatic creatinine method.

For further information on how this will effect your results please refer to:

http://www.heftpathology.com/alphaindex/downloads/n.html

Enzymatic creatinine is currently not a UKAS accredited test. It will be assessed in October 2018.

Creatinine (Urine)

Creatinine (Urine)

Male:       5.1-14.2 mmol/L          7.7-21.3 mmol/24hrs

Female:  3.9-9.4 mmol/L             5.9-14.1 mmol/24hrs

 

Creatinine Clearance

Creatinine Clearance

Calculation

Creatinine Clearance =  U x V
                                        PxT
where U = urine creatinine concentration in μmol/L, V = urine volume in mL, P = serum creatinine in μmol/L and T = time of collection in minutes.
 
Values for urinary and plasma (serum) creatinine must be in the same units.
 

NB. Urine creatinine is usually reported in mmol, and the value should be multiplied by 1000 for use in the equation.

Female  CC = 72 – 110 mL/min
Male      CC = 94 – 140 mL/min
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